[Solved] 2 Page Minimum Resources

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[Solved] 2 Page Minimum Resources

review the AACN DNP Essentials document and reflect on the competencies presented. Think of  your personal and academic goals and consider how those goals align with both Walden University’s mission and vision and with the AACN DNP Essentials. Reflect on the social determinants of health framework and consider how your academic and professional goals might align with addressing these elements as a DNP-prepared nurse

  • Explain how your academic and professional goals align with Walden’s vision, mission, social change message, social determinants of health, and university outcomes as well asand the AACN DNP Essentials. Be specific.
  • Explain how you plan to incorporate social change throughout your program of study and in professional practice. Be sure to include how social change may contribute to your practicum/field experience and your role in professional practice.

    2 page minimum Resources 

[Solved] Advanced Psychiatric Mental Health

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[Solved] Advanced Psychiatric Mental Health

Initial Post

Foundational Neuroscience

The term foundational neuroscience refers to a three-course series that explores the structure and function of the nervous system – from the inner workings of a single nerve cell to the staggering complexity of the brain and the social interactions it enables (Harvard Edu. 2020)

According to studies, cases of mental and psychiatric conditions have been on the increase. As a result of this crisis, there is a need for quality psychiatric health care that encompasses appropriate knowledge by health practitioners of dealing with these issues (Harvard Edu. 2020). This involves a deep understanding of the pathophysiology of psychiatric disorders and understanding the impact of certain drugs on a specific disorder. It has been advocated those psychiatric patients be referred to as clients as it is more favorable for mental health. This discussion will address the agonist and antagonistic agents, g- g-couple proteins and ion-gated channels, and the role of epigenetics in psychopharmacology.

The agonist-to-antagonist spectrum of action of psychopharmacologic agents.

 Also known as the agonist spectrum, describes the range of effects that can be exerted by psychopharmacological agents. For example, it describes how some medications/drugs can stimulate receptors in the brain just like natural neurotransmitters and how other drugs can block/prevent this action (Stahl, 2013). For example, benzodiazepines (Valium) increase/mimic the GABA neurotransmitter (agonist) and Flumazenil decreases/blocks this neurotransmitter (antagonist).  The agonist-to-antagonist spectrum psychopharmacologic agents work at the sites of neurotransmission and conduct their effects based on a spectrum of agonist-to-antagonist (Stahl, 2013). The spectrum ranges from true agonist to inverse agonist. Some examples of effects between the two ends are partial agonist, silent antagonist, and partial inverse agonist.

Agonist

Agonist is a chemical substance that binds to and activates certain receptors on cells. Agonistic drugs are drugs that modify or change the state of receptors to trigger a biological response. Oxycodone, morphine, heroin, fentanyl, methadone, and endorphins are all examples of opioid receptors (Stahl, 2013). According to Stahl (2013), a full agonist allows the receptor to fully open the ion channel which allows the downstream signal transduction to occur maximally. An agonist is any drug that activates specific brain receptors, thereby causing the full effects of the drug to take place

Partial Agonist

A partial agonist is any drug that acts as an agonist, but the degree of receptor activation is reduced. The receptor has a resting state. When a partial agonist is in contact with the receptor in a resting state, the ion channel will partially open, allowing some downstream signal transduction (Stahl, 2013).

Antagonist

Antagonistic drugs refrain or stop minimizing any biological response by blocking any presenting receptors (Camprodon et al., 2016). The antagonist will return the receptor to a resting state (Stahl, 2013). Constitutive activity still occurs in the presence of an antagonist, which is the minor ion flow despite being in a resting state (Stahl, 2013). When a drug is classified as an antagonist, it means that it blocks the receptors, so they are not able to bind to the agonist. In the realm of opioids, an example of an agonist is Heroin, the antagonist is Naloxone, while the the partial agonist is Buprenorphine. To illustrate this example, Heroin is an addictive agonistic substance. In the case of heroin overdose, Naloxone, an antagonist can be used to reverse the binding and block receptors from binding with free-floating Heroin. The pharmacological treatment for heroin addiction often includes the partial agonist, Buprenorphine. Buprenorphine allows partial binding to opioid receptors, thus reducing withdrawal symptoms and curving drug cravings (Camprodon et al., 2016).

Inverse Antagonist

Inverse agonists are the last type on the spectrum. Inverse agonists cause receptor changes, leading to the closing of the ion channels and eventual inactivation if not reversed (Stahl, 2013).

G Couple Proteins and ion-gated channels

G couple proteins and ion-gated channels are both major membrane receptors. The binding of a signaling molecule to a G-coupled protein receptor results in G protein activation, which in turn triggers the production of any number of second messengers, leading to G-coupled proteins helping to regulate a person’s immune system, growth, taste, smell, behavior, and mood (Rosenbaum et.al, 2009). Gated ion channels are proteins that open to allow ions such as Na+, K+, Ca2+or Cl- to pass through the cell membrane in response to a ligand such as a neurotransmitter (Stahl, 2013).

Comparison between G-couple protein and ion-gated channel and their actions

 The ion-gated channels, commonly known as, ligand-gated channels consolidate rapid postsynaptic responses while G-proteins consolidate slow postsynaptic responses (Camprodon et al., 2016). In terms of structure, the ion-gated channels are pores that open and close at the ligand binding while G-proteins include a single polypeptide. The G-protein receptors interact with proteins while ion channels regulate the flow of ions. G Couple Proteins and Ion-Gated Channels. Neurotransmission occurs not only electrically such as with ion-gated channels but also occurs chemically at receptors. G-protein linked receptors have seven transmembranes that each have a receptor to bind a neurotransmitter (Stahl, 2013). The first messenger is an extracellular neurotransmitter, and it passes the message to the second messenger system (Stahl, 2013). When the first messenger binds to the receptor, it changes the shape allowing the binding of the G protein, which then changes confirmation to allow binding with an enzyme (Stahl, 2013). Once bound, cyclic adenosine monophosphate is synthesized leading to the second messenger continuing neurotransmission to other messengers (Stahl, 2013).

Explain how the role of epigenetics may contribute to pharmacologic action.

Epigenetics not only has a role in the development of psychiatric and mental health disorders, but it can also affect the way medications work for each person. DeSocio (2016) describes synaptogenesis as the development of new neuronal connections that occur more rapidly during childhood but continue through adulthood as well. When stress hormones are present at high levels, there is a decrease in synaptogenesis (DeSocio, 2016).  Epigenetics can be defined in many ways, but the basis is that gene function can be altered without changing the DNA and RNA code. This functional change in the gene can also be inherited (Camprodon & Roffman, 2016, p. 64). As a result, epigenetics can determine how a medication works and what illnesses an individual may develop. If a medication works on a specific gene, but that gene has an altered function, the drug’s efficacy may change. For example, individuals with altered dopamine formation and receptor binding may have an affinity toward drug addiction or a degree of natural tolerance (Saad et al., 2019, p. 1534). For non-addictive substances, this logic holds as to why some medications work for one person, but not another individual.

Explain how this information may impact the way you prescribe medications to patients. Include a specific example of a situation or case with a patient in which the psychiatric mental health nurse practitioner must be aware of the medication’s action.

The above concepts of foundational neuroscience analyses will have an impact on how and what a psychiatric mental health nurse practitioner will prescribe to all clients. The knowledge learned will enable the provider to determine exactly which medication will help each client the most for their illness whether it be short-term or long-term. The PMHNP will be made more aware of the effectiveness of all medications used and their action for the client’s individual needs. Examples of the effects and actions are used to treat clients with anxiety and insomnia such as benzodiazepines which have an immediate effect on clients. Benzodiazepines can act as a full agonist on a positive allosteric modulator (PAM) by exhibiting an anxiolytic, hypnotic, anticonvulsant, amnestic, and muscle relaxant action (Stahl, 2013). Benefit-risk assessments must be considered by all providers when prescribing specific drugs to certain groups of clients. Extra care should be considered for clients, such as pregnant women, children, and the elderly because of their vulnerable states (Alshammari, 2016). An advanced psychiatric mental health nurse practitioner must be able to match the client’s symptoms with the correct medication to sometimes control their difficult symptoms (Laureate Education, 2016).

References

Alshammari, T. M. (2016). Drug safety: The concept, inception, and its importance in patients’ health. Saudi Pharmaceutical Journal, 24 (4), 405-412. doi: 10.1016/j.jsps.2014.04.008

Camprodon, J. A., & Roffman, J. L. (2016). Psychiatric neuroscience: Incorporating pathophysiology into clinical case formulation. In T. A. Stern, M. Favo, T. E. Wilens, & J. F. Rosenbaum. (Eds.), Massachusetts General Hospital psychopharmacology and neurotherapeutics (pp. 1-19). Elsevier.

DeSocio, J. E. (2015). Epigenetics: An Emerging Framework for Advanced Practice Psychiatric Nursing. Perspectives in Psychiatric care/Volume 52, Issue 3/.201-207. https://doi.org/10.1111/ppc.12118Links to an external site.

Harvard University (2020). Fundamentals of Neuroscience: Electrical Properties of the Neuron. Retrieved September 4, 2023, from https://www.edx.org>lrstn>harva…

Laureate Education (Producer). (2016i). Introduction to psychopharmacology [Video file]. Retrieved from https://class.waldenu.eduLinks to an external site.

Rosenbaum, M. J., Clemmensen, L. S., Bredt, D. S. et al. Targeting receptor complexes: a new dimension in drug discovery. Nat Rev Drug Discov 19, 884-901 (2020). https://doi.org/10.1038/s41573-020-0086-4

Saad, M. H., Rumschlag. M., Guerra, M. H., Savonen, C. L., Jaster, A. M., Olson, P. D., Alazizi, A., Luca, F., Pique-Regi, R., Schmidt, C. J., & Bannon, M, J. (2019). Differentially expressed gene networks, biomarkers, long noncoding RNAs, and shared responses with cocaine identified in the midbrains of human opioid abusers. Scientific Reports, 9, pp. 1534. Retrieved from https://www.nature.com/articles/s41598-018-38209-8

Stahl, S. M. (2013). Stahl’s Essential Psychopharmacology: Neuroscientific basis and practical applications (4th ed.). New York, NY: Cambridge University Press.

[Solved] Mood Improvement Without Inducing

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[Solved] Mood Improvement Without Inducing

My main post in response to each of the following: 

  1. Explain the agonist-to-antagonist spectrum of action of psychopharmacologic agents, including how partial and inverse agonist functionality may impact the efficacy of psychopharmacologic treatments.

The agonist-to-antagonist spectrum of action is a concept used in psychopharmacology to describe the various ways to interact with receptors to control the neurotransmitter activities in the nervous system. These interactions can have different effects influence behavior and mood. To understand this spectrum, it’s important to grasp the concepts of agonists, antagonists, partial agonists, and inverse agonists:

Agonists are substances that activate or stimulate a receptor when they bind to neurotransmitters, leading to an increase in neurotransmitter activity. For example, drugs that function as serotonin agonists can mimic the effects of serotonin in the brain, potentially resulting in improvements in mood and anxiety.

Antagonists are substances that bind to receptors but do not activate them. Instead, they block or inhibit the action of neurotransmitters. Antagonists can be used to reduce the effects of certain neurotransmitters. For example, Naloxone is an antagonist. It is an opioid receptor antagonist. it rapidly reverses the effects of opioids, such as heroin, and morphine by competitively binding to opioid receptors. This action can rapidly reverse the life-threatening effects of opioid overdose in emergencies. it can be a life-saving intervention when used promptly.

Partial agonists are substances that activate a receptor to a lesser extent compared to a full agonist. They have a moderate effect on receptor activity. Partial agonists are often used in psychopharmacology to achieve a more subtle or balanced effect. For example, a partial serotonin agonist might provide some mood improvement without inducing extreme mood swings.

Inverse agonists are substances that produce the opposite effect of an agonist. They bind to a receptor and reduce its baseline activity. They can turn down the activity of a receptor even in the absence of an agonist. Depending on the receptor system targeted, inverse agonists may have a sedative or calming effect, which can be useful in treating conditions associated with over-activity in specific neurotransmitter systems.

  1. Compare and contrast the actions of g couple proteins and ion-gated channels.

G protein-coupled receptors (GPCRs) and ion-gated channels are both essential components of neurotransmission in the nervous system. There are two distinct types of cell membrane proteins involved in signal transduction and the regulation of cellular responses. They play different roles in the process. They both are activated by the binding of neurotransmitters to their receptor sites on the postsynaptic neuron.

GPCRs work indirectly by activating intracellular signaling pathways. When a neurotransmitter binds to a GPCR, it triggers a cascade of events that involves the activation of G proteins. These G proteins then interact with other signaling molecules, leading to various intracellular responses. GPCRs can regulate a wide range of cellular responses, including changes in gene expression, modulation of enzyme activity, and second messenger production. They have a broad and diverse range of functions.

Ion-gated channels, also known as ligand-gated ion channels, work directly by allowing the flow of ions across the cell membrane upon neurotransmitter binding. When a neurotransmitter binds to the channel’s receptor site, the channel opens, allowing ions to pass through, which can result in changes in the membrane potential and cellular excitability. Their function is more focused on altering the electrical properties of the neuron.

GPCRs are versatile and can modulate various intracellular pathways, while ion-gated channels directly control ion flow and cellular excitability. The choice between these mechanisms depends on the specific needs of the synaptic signaling and the desired cellular response.

  1. Explain how the role of epigenetics may contribute to pharmacologic action.

Epigenetics involves alterations in gene expression or cellular phenotype. Epigenetic modifications can influence how genes are turned on or off, and these modifications can be influenced by pharmacological agents. Epigenetic modifications, such as DNA methylation and histone modifications, can impact the accessibility of genes to the cellular transcriptional machinery. Pharmacological agents can influence these epigenetic marks, either directly or indirectly, to regulate gene expression. Epigenetic changes can affect the expression of enzymes involved in drug metabolism. Understanding and harnessing the epigenetic aspects of drug action can lead to more effective and personalized therapeutic interventions.

  1. Explain how this information may impact the way you prescribe medications to patients. Include a specific example of a situation or case with a patient in which the psychiatric mental health nurse practitioner must be aware of the medication’s action.

As a Psychiatric Mental Health Nurse Practitioner (PMHNP), comprehending the implications of psychopharmacologic actions can profoundly shape my approach to prescribing medications for patients. The PMHNP’s knowledge of psychopharmacology plays a vital role in improving patient outcomes.

Imagine a patient, with a history of major depressive disorder. The patient has tried multiple antidepressant medications over the years with limited success and is currently experiencing a severe depressive episode with significant impairment in her daily life. As a PMHNP, I have learned psychopharmacology would be well-versed in the mechanisms of action of different antidepressant classes. For example, I would know that selective serotonin reuptake inhibitors (SSRIs) work by increasing the availability of serotonin in the brain by inhibiting its reuptake. I would also be aware that other classes like serotonin-norepinephrine reuptake inhibitors (SNRIs) and atypical antidepressants target different neurotransmitters.

By tailoring the medication choice to patient-specific needs, monitoring for side effects, and maintaining open communication, I can increase the likelihood of a successful treatment outcome for a patient’s depression.

Reference:

Mental Health TV. (2022, Oct 7).  Psychopharmacology-Module fourLinks to an external site. [Video]. YouTube.https://www.youtube.com/watch?v=46Ioy6SSta4&t=89sLinks to an external site.

Mental Health TV. (2022, Oct 7).  Psychopharmacology-Module five [Video]. YouTube. https://www.youtube.com/watch?v=1ynTQB59KW0&t=16s

Stahl, S. M. (2021). Stahl’s essential psychopharmacology: Neuroscientific basis and practical applications (5th Ed.) Cambridge University Press.

The University of British Columbia. (n. d.). Neuroanatomy videosLinks to an external site.. http://neuroanatomy.ca/videos.htmlLinks to an external site.

[Solved] Four Responses Offered

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[Solved] Four Responses Offered

 

1) Watch the entire scenario. In the scenario assignment, you are asked to reflect on responses to the presented scenario. 

2) Fill out the template attached below

3) Compose the last question on the template reflection in a Word document and be sure to address, at a minimum, the following questions:

*Why do you feel the way you do about the issue presented?

*Of the four responses offered in the scenario, which do you think is the most ethical and why?

*Which ethical theory would you use to support your stance? Why does this theory work?

4)  Support your conclusions with evidence and specific examples from the textbook, including a minimum of one theory of ethics to defend your stance.

[Solved] Newly Diagnosed Stage 1

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[Solved] Newly Diagnosed Stage 1

A 56-year-old patient with newly diagnosed stage 1 hypertension has been referred to you for counseling regarding lifestyle modifications. He is married, with four children — two in high school, two in college. His job as a senior vice-president for a major retail chain requires that he work long hours and frequently eat at restaurants. He smokes two packs of cigarettes a day, has a body mass index (BMI) of 29 kg/m2, and a waist-hip ratio of 1.6. He usually drinks one to two dry martinis to relax after he gets home from work.

  1. How would you develop a realistic plan to help this patient reduce his blood pressure and prevent complications?
  2. Which risk factors would be among your top two or three priorities for this patient, and what interventions or recommendations would you provide for modifying these?

Instructions: 1 pg to 1 1/2 pg is long enough. APA style discussion post. has to have 3 references.

[Solved] Current Knowledge Base

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[Solved] Current Knowledge Base

 

Therapeutic communication is important to ensure patients are part of treatment planning. Provide discussion (250-350 words) of the following:

  1. How would you evaluate a patient’s ability to understand your instruction and their current knowledge base about their problem? What characteristics of the patient would be helpful?
  2. How would you be certain that the patient understands your medication instruction?
  3. What methods of therapeutic communication would be useful in advanced practice?

instructions: length of 1 page to 1/2 is long enough. APA style. Has to have 3 references.

[Solved] Ethnic Group

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[Solved] Ethnic Group

Use PowerPoint or similar software to develop a slide presentation on a diversity topic of your choice.

 Choose one of the following topics and begin researching for your presentation:

  • Racial stereotypes and racism (select one racial or ethnic group).
  • Immigration.
  • Religion and spirituality.
  • Gender stereotypes and sexism.
  • Sexual orientation and heterosexism.
  • Age stereotypes and ageism.
  • Mental disabilities.
  • Physical disabilities.

[Solved] White Americans ’ Self

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[Solved] White Americans ’ Self

Overview

To prepare for this discussion, be sure you review the following resources:

Citations:

National Association of Social Workers. (2020, August 21). Social workers must help dismantle systems of oppression and fight racism within the social work profession. https://www.socialworkers.org/News/News-Releases/ID/2219/Social-Workers-Must-Help-Dismantle-Systems-of-Oppression-and-Fight-Racism-Within-Social-Work-Profession

The Late Show With Stephen Colbert. (2020, June 26). Dr. Ibram X. Kendi: Creating a more equitable society is in white Americans’ self interest [Video]. YouTube. https://www.youtube.com/watch?v=dCUOX3NMd4U&t=50s

Prompt

Respond to the following in your discussion board post:

  • What is the main point that you took away from Dr. Ibram X. Kendi’s talk?
  • In your own words, what does it mean to be an antiracist?
  • The NASW News Release speaks to social workers about challenging our own racism. What is one area of growth you would like to implement after completing the module page activities and videos?
  • What are other ways in which social workers can help fight racism?

[Solved] Slide Must Provide Detailed

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[Solved] Slide Must Provide Detailed

 COVID-19 Pandemic and Mental Health in KSA (100 points)Examine how the COVID-19 Pandemic influenced patients with mental health disorders and their treatment plans. Use this week’s required readings, recommended readings, the textbook, and your own research to develop a PowerPoint presentation describing:

  • An overview of symptoms, risk factors, and prevalence of mental health disease in KSA
  • Best practices for diagnosis, early identification, and treatment of mental illness in a pandemic
  • What are the contemporary and future challenges related to the healthcare system management of this mental illness in a pandemic?
  • Recommendations on how to address these challenges going forward.

Your presentation should meet the following structural requirements:

  • Be 10-12 slides in length, not including the title or reference slides.
  • Be formatted according to APA writing guidelines. 
  • Provide support for your statements with citations from a minimum of six scholarly articles. These citations should be listed in the Notes section of the slide in which they appear. Two of these sources may be from the class readings, textbook, or lectures, but four must be external. 
  • Each slide must provide detailed speaker’s notes to support the slide content. These should be a minimum of 100 words long (per slide) and must be a part of the presentation. The presentation cannot be submitted in PDF format, which does not make notes visible to the instructor. Notes must draw from and cite relevant reference materials. 
  • Utilize headings to organize the content in your work.

[Solved] Assist Would Likely Help

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[Solved] Assist Would Likely Help

 

Homework Purpose: In this assignment, you will be completing a developmental assessment of a specific person and comparing them to established norms, developmental milestones, and theories and determining which developmental tasks have been met and unmet.

Note: The assessment is not a chronological lifespan report of development from the viewpoint of a single theorist. It should focus on the subject’s current period of life utilizing multiple theories. However, if the subject has unmet tasks, you can examine earlier periods of life influential to the delay.

Homework Instructions:

1. Select a subject (person at least three years old)  you know well enough to complete a developmental assessment. 

2.    Collect and provide a brief overview of the subject’s biographical information, including information such as their age, gender, family structure and living environment, education or employment setting, family socio-economic status, religious affiliation, ethnicity, or cultural elements etc.  

3.    Identify and report the subject’s current age period of development per textbook based on their chronological age. 

•    Early Childhood; Middle Childhood; Late Childhood; Adolescence; Emerging Adulthood, Early Adulthood; Middle Adulthood; Late Adulthood

4. Thoroughly review the theories, skill concepts, and established norms and milestones from the course material that are relevant to the subject’s current age period. 

5. Select several topics in each of the three developmental domains (physical, cognitive, and psychosocial) that you find interesting and relevant to the individual.

6. Describe and compare information about the subject’s functioning in your selected topic areas to cited normative information.

7. Assess the subject to determine if they have met or not met the developmental expectations according to the textbook and other associated course materials. Could you ensure the inclusion of various theoretical perspectives is discussed in the course material?

8. Identify and suggest measures to assist in the healthy development of an unmet or delayed topic. If areas of development are not found to be unmet or delayed, suggest measures to maintain or further strengthen an already achieved topic area. The suggested measures to assist or maintain need to include clear reasoning supported by normative information, i.e., a statement regarding why the measure to assist would likely help address the particular developmental objective. 

Homework Requirements:  

The minimum length of the homework is four pages (not including the title or reference pages). The typical length required to cover all the rubric areas thoroughly is 4-6 pages. 

You can use the course material as the main cited reference and use at least one other resource. The additional reference should be educational and published within the last 5 years. 

Adhere to all APA style guidelines, including cover and reference page formatting, spacing, font size, margins, page numbers, and in-text citation formatting. 

The quality and effectiveness of your homework is essential. Please use professional/scholarly language that follows basic grammar and punctuation rules and maintains accurate spelling. Please avoid overly casual or conversational speech.

  Book: Lilly, M., & Valentine-French, S. (2019). Lifespan Development: A Psychological Perspective Second Edition. http://creativecommons.org/licenses/by-nc-sa/3.0/